Preventive role of Crataegus monogyna on sperm quality and testis oxidative stress against copper-induced toxicity
نویسندگان
چکیده
منابع مشابه
Crataegus monogyna aqueous extract ameliorates cyclophosphamide-induced toxicity in rat testis: stereological evidences.
Cyclophosphamide (CP) is extensively used as an antineoplastic agent for the treatment of various cancers, as well as an immunosuppressive agent. However, despite its wide spectrum of clinical uses, CP is known to cause several adverse effects including reproductive toxicity. Crataegus monogyna is one of the oldest pharmaceutical plants that have been shown to be cytoprotective by scavenging fr...
متن کاملChemoprotective effect of Crataegus monogyna aqueous extract against cyclophosphamide-induced reproductive toxicity
Cyclophosphamide (CP) is extensively used as an antineoplastic agent for treatment of various cancers, as well as an immunosuppressive agent. However, despite its wide spectrum of clinical uses, CP is known to cause several adverse effects including reproductive toxicity in humans and experimental animals. Crataegus monogyna is one of the oldest medicinal plant has been shown to be cytoprotecti...
متن کاملP-87: Effect of Oxidative Stress on Sperm quality and Testis Histopathology in Mature Male Mice
Background: Infertility is a major clinical and worldwide reproductive problem that affects approximately 15% of young couples. The male factors are responsible for periphery 50 percent of these cases. Recently, the generation of oxidative stress, also described as an imbalance between the production of Reactive oxygen species (ROS) and the body’s antioxidant defence mechanisms, in the male rep...
متن کاملP-40: Silymarin Prevents and Protects from the Doxorubicin-induced Oxidative Stress in Testis and Improves Sperm Quality in Rats
Background: Doxorubicin (DOX) as an antracycline is used antineoplastic agents against tumors. Although DOX has been recognized as a potent and effectiveness anticancer compound, there are however plenty of reports indicating its toxicity against the heart, liver and testis, which hampers its clinical use. This study aimed to investigate the preventive and protective effects of Silymarin (SMN) ...
متن کاملAttenuation of Cyclosporine-Induced Sperm Impairment and Embryotoxicity by Crataegus monogyna Fruit Aqueous Extract
OBJECTIVE Cyclosporine (Cs), a cyclic undecapeptide with potent immuno suppressive activity, causes several adverse effects including reproductive toxicity. This study aims to examine the ability of Crataegus monogyna aqueous fruit extract as an antioxidant to protect against Cs-induced reproductive toxicity. MATERIALS AND METHODS In this experimental study, 32 adult male Wistar rats were div...
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ژورنال
عنوان ژورنال: Ankara Universitesi Eczacilik Fakultesi Dergisi
سال: 2020
ISSN: 1015-3918
DOI: 10.33483/jfpau.716103